Evening Primrose Oil Soft Capsule 1000mg Quick Release EPO Softgels

Evening Primrose Oil Soft Capsule 1000mg Quick Release EPO Softgels

What is Evening Primrose Oil?

Evening primrose (Oenothera biennis) is a plant native to the Americas. Its yellow flowers open at sunset. The oil in its seeds contains omega-6 fatty acids.

Evening primrose oil contains gamma-linolenic acid (GLA). GLA is an omega-6 essential fatty acid that has anti-inflammatory effects in the body.

People use evening primrose oil for premenstrual syndrome (PMS), menopause symptoms, arthritis, high cholesterol, acne, and many other conditions, but there is no good scientific evidence to support these uses.

About this item

• Customized packing, in bulk packing or in bottles

• A Dietary supplement, for human consumption

• We do Contract Manufacturing (OEM/ODM)

• GMP Facility Quality Assured.

Function and Application

Anti inflammation

GLA (γ-linolenic acid) in human body through physiological and biochemical reactions will produce an endophytic substance -- prostaglandin E1, prostaglandin E1(PGE1)

It can replace the physiological effects of PGE2 normally produced in the body. However, PGE1 has a strong smooth muscle relaxation effect on PGE2, so it is speculated that it will help relieve asthma and reduce blood pressure. Although many general-dose clinical trials have not supported this claim, for endogenous inflammatory factors, atopic eczema (P. Edben, et al., A study of evening primrose seed oil in atopic asthma,) has proved to be effective. prostaglandins Leukot Essent Fatty Acids 35(2): 69-72 Feb. 1989). This study led by a group of Swiss biochemists led by Biagi treated a group of children with atopic dematitis caused by immune insufficiency caused by abnormal IgE immunoglobulin value with evening primrose oil. The results showed that GLA could effectively increase the concentration of dihomogamma linolenic acid (DGLA), an anti-inflammatory endonobiological progenicant, and a significant improvement in symptoms could be found in groups with high ingestion of evening primrose oil. With a series of clinical trials demonstrating the anti-inflammatory effects of evening primrose oil, biochemists began trying to apply the oil to inflammatory symptoms caused by autoimmune reactions such as multiple spondylitis and lupus erythematosus. The results were also satisfactory (P.C. Calder, The effect of fatty acids on lymphocyte functions, Braz J Med Biol Tes, 1993; 9(26): 901-917). However, it is worth noting that deep-sea fish oil (W-3 oleic acid) also has this effect, so unless you are a vegetarian, primwort oil and deep-sea fish oil may be used in combination for autoimmune inflammatory relief.

Relief from premenstrual symptoms

When we find our usual cute and gentle female companion suddenly depressed and grumpy, our most intuitive guess might be "Oh, she must be the one." "Most women have to spend five to ten days a month with their 'best friend' for almost half of their life. However, due to hormonal changes that begin two to three days before menstruation, In addition, during menstruation, the concentration of inflammatory factor Prostaglandin in the body will increase due to the flaking and bleeding of endometrium. The GLA contained in evening primrose oil can inhibit the concentration of inflammatory prostaglandin and reduce the uncomfortable reaction of PMS. There was a clinical trial of evening primrose oil as a treatment for severe breast swelling caused by PMS, The effect of evening primrose oil was similar to that of traditional oral hormonal preparations for breast hyperpain (P.M. Genolet, et. Al., Diagnosis and treatment of mastodynial, Red Med Sruisse Romande, 1995; 115(5): 385-390). Another problem women face is osteoporosis, so how to reduce calcium loss becomes an important topic. According to a study on mice, a group fed evening primrose oil for four weeks had significantly lower levels of calcium in their urine, and mice with hypercalcemia, It is also meaningful to prevent calcium loss (I. Tulloch et. Al., Evening primrose oil reduces urinary calcium excretion in both normal and hypercalciuric rats. 1994, 22(4) 227-230). This study also supports the effect of taking evening primrose oil on reducing calcium loss and preventing osteoporosis. Since evening primrose oil is beneficial to women's physical health, it should be a priority choice for women in the health food market.

Lower blood clots

Like deep-sea fish oil, evening primrise oil is a very polyunsaturated essential fatty acid, which can replace inflammatory endogenic factors produced by peanut oil tetraenoic acid in the body, such as prostaglandins, leucotrienes and Thrombosane X2. Therefore, in addition to anti-inflammation, Evening primrose oil also has the effect of reducing coagulation response and preventing thrombosis (E.J. Steven, et al., Prostacyclin release in experimental diabetes: effect of evening primrose oil, Prostaglandins Leukot Essent Fatty Acids, 1993 Sep; 49(3): 699-701).

In addition, biochemist Fan published in the Journal of Vascular Biomedicine in 1995 that GLA can reduce the proliferation of mast cells and smooth muscle cells, and reduce the incidence of atherosclerosis.

Evening primrose oil, in addition to its protective effects against cardiovascular disease, which is common among the elderly, is also useful for another age-related disease, diabetes. Neuroatrophy is a common side effect of diabetes. Scientists also found that evening primrose oil can protect nerve cells and reduce the incidence of disease (N.E. Cameron, et al., Br. J. Pharmacol, 1993; 109 (4), 972-979; C.D. Dines, et al., Eur J Pharmacol, 1995 Aug; 281(3): 303-309). British biochemist Grant et al. fed evening primrose oil to a group of mice suffering from gestational diabetes, and found that the weight and health status of the mice were normal compared with the mice that did not ingest evening primrose oil. They also found that evening primrose oil could reduce the incidence of diabetes. Although this was not an experiment on human subjects, taking evening primrose oil as the maintenance of chronic diseases. It's actually a good choice!

Anti-cancer effect

When it comes to cancer, most people may regard it as a major killer that will end human life, and the treatment after the event is not as meaningful as the prevention before the event. Therefore, no matter what kind of health food, most of us will try to "find a way" to associate with "anti-cancer". The anti-cancer effect of evening primrise oil is only limited to the research stage with mice as samples. And the reason it works against cancer is that evening primrose oil "reduces" fat peroxidation in mouse fat cells, because peroxidation creates free radicals, (S. Kokura, et al., Efficacy of hyperthermis and polyunsaturated fatty acids on experimental carcinoma; (S. Kokura, et al., Efficacy of hyperthermis and polyunsaturated fatty acids on experimental carcinoma; Cancer Res, 1997 Jun; 57 (11) : 2200-2202).

So evening primrose oil is thought to have an anti-tumor effect. In addition, scientists have also found that GLA blocks the fusion of normal blood vessel cells with tumor endothelial cells, and thus, It can also slow the progression of cancerous changes (W.G. Jiang et al., GLA regulates gap junction communication in endothelial cells and their inter action with tumor cells., Prostaglandins Leukot Essent Fatty acids, 1997 Apr; 56(4): 307-316).

Pharmacological Action

1. Lowering blood lipids and anti-atherosclerosis effects: Evening primrose oil by inadministration of 5ml/kg can reduce the levels of serum total cholesterol, low density lipoprotein cholesterol and very low density lipoprotein cholesterol in rats induced by high fat diet. And can significantly increase HDL cholesterol levels. Hyperlipidemia and atherosclerosis caused by cholesterol and lard were fed to rabbits, and evening primrose oil was inlavated with 0.1-0.3ml/kg for 8 weeks. When the fatty acid sodium of evening primrose oil was 4.1g/kg and continued gavage for 150 days, the formation of aortic plaque was significantly reduced, and the inhibition rate of evening primrose oil reached 47.6%-73.5%.

2. Weight loss effect: Evening primrose oil 0.3-1ml/kg, continuous 8 weeks of gavage, can prevent hypothalamic obesity caused by subcutaneous injection of large dose of sodium glutamate (3mg/g body weight). Decreased triglyceride in animal blood and increased HDL cholesterol; Moreover, it can inhibit the increase of adipocytes and thicken the intestinal villi of glutamate mice, thus regulating the gastrointestinal absorption function and reducing the accumulation of fat in the body.

3. Anti-fatty liver effects: Evening primrose oil (0.3ml/kg), and its 5% sodium salt (2ml/kg) and 5% sodium salt (6ml/kg) by gavage had good anti-fatty liver effects on rats induced by ethionine. Significantly reduced the content of triacylglycerol in fatty liver and inhibited the occurrence of fatty liver.

4. Anti-arrhythmic effect: Evening primrose oil and its sodium salt have significant prevention and control effects on the arrhythmia induced by aconitine in rats, the arrhythmia induced by toxoside G in guinea pigs and the arrhythmia induced by barium chloride in rabbits, especially the arrhythmia induced by barium chloride.

5. Anti-inflammatory effects: Evening primrose oil significantly inhibited the inflammation caused by a variety of inflammatory agents. The ear swelling of mice induced by 2-4ml/kg administration of evening primrose oil was significantly inhibited by carrageenan and foot swelling caused by histamine, prostagstagin E2 (PGE2), scalding, formaldehyde and nystatin in normal and adrenal rats. Inhibit the release of PGE and the inflammatory effect of PGE and histamine, inhibit the release of bradykinin, and stabilize the lysosome membrane. Its anti-inflammatory effect is not through excitation of pituitary-adrenal cortex system, but perhaps through inhibition of mediators release and inflammatory, exudation, leukocyte chemotaxis and connective tissue hyperplasia in the inflammatory process.

6. Other effects: Evening primrose oil can inhibit platelet aggregation and prevent thrombosis. When the final concentrations of evening primrose oil were 1.80μl/ml and 2.7μl/ml, the inhibitory rates of ADP-induced platelet aggregation in rabbits were 41.8%±6.9% and 50.0±6.3%, respectively. It can significantly inhibit lipid peroxidation in mouse liver. The activity of catalase in blood of mice was significantly enhanced. Evening primrose oil (0.8g/kg), intragastric administration once a day for 90 days, can reduce the urine protein content of rats with chronic renal failure, selectively improve the urine protein, slow the rise of blood creatol level, and the pathological changes are mild. These changes were consistent with decreased blood cholesterol levels and increased levels of prostaglandin E2 and 6-keto-prostaglandin F1α in renal tissue.